I came into this expecting to reject it as some kind of stupid performance issue, but no. This is legitimate and strange.
09:41:037 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01dee609 (byte 0x0077b9824), length 0x4000
09:41:037 Core\HW\DVD\FileMonitor.cpp:87 W[FileMon]: 26,384 kB Pack/SamMax201/4_SamMax201_wii_music.ttarch
09:41:286 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa13b9 (byte 0x006a84ee4), length 0x4000
09:41:287 Core\HW\DVD\FileMonitor.cpp:87 W[FileMon]: 7,413 kB Pack/SamMax201/3_SamMax201_wii_sfx.ttarch
09:41:288 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa23b9 (byte 0x006a88ee4), length 0x4000
09:41:294 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:41:369 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x02174cea (byte 0x0085d33a8), length 0x4000
09:41:369 Core\HW\DVD\FileMonitor.cpp:87 W[FileMon]: 2,669 kB Pack/SamMax201/5_SamMax201_wii_amb.ttarch
09:41:889 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ab7eaa (byte 0x006adfaa8), length 0x4000
09:41:889 Core\HW\DVD\FileMonitor.cpp:87 W[FileMon]: 7,413 kB Pack/SamMax201/3_SamMax201_wii_sfx.ttarch
09:41:889 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ab8eaa (byte 0x006ae3aa8), length 0x4000
09:42:884 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ad5b84 (byte 0x006b56e10), length 0x4000
09:42:884 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ad6b84 (byte 0x006b5ae10), length 0x4000
09:43:191 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01def609 (byte 0x0077bd824), length 0x4000
09:43:191 Core\HW\DVD\FileMonitor.cpp:87 W[FileMon]: 26,384 kB Pack/SamMax201/4_SamMax201_wii_music.ttarch
09:43:484 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a93b26 (byte 0x006a4ec98), length 0x4000
09:43:484 Core\HW\DVD\FileMonitor.cpp:87 W[FileMon]: 7,413 kB Pack/SamMax201/3_SamMax201_wii_sfx.ttarch
09:43:484 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a94b26 (byte 0x006a52c98), length 0x4000
09:43:620 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:43:621 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa13b9 (byte 0x006a84ee4), length 0x4000
09:43:622 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa23b9 (byte 0x006a88ee4), length 0x4000
09:43:625 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa33b9 (byte 0x006a8cee4), length 0x4000
09:43:627 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa13b9 (byte 0x006a84ee4), length 0x4000
09:43:628 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa23b9 (byte 0x006a88ee4), length 0x4000
09:43:629 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa33b9 (byte 0x006a8cee4), length 0x4000
09:43:629 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa21b9 (byte 0x006a886e4), length 0x4000
09:43:630 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa31b9 (byte 0x006a8c6e4), length 0x4000
09:43:631 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa15b9 (byte 0x006a856e4), length 0x4000
09:43:631 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa25b9 (byte 0x006a896e4), length 0x4000
09:43:633 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa35b9 (byte 0x006a8d6e4), length 0x4000
09:43:633 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa13b9 (byte 0x006a84ee4), length 0x4000
09:43:635 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa23b9 (byte 0x006a88ee4), length 0x4000
09:43:685 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:43:685 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa33b9 (byte 0x006a8cee4), length 0x4000
09:43:685 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a923f6 (byte 0x006a48fd8), length 0x4000
09:43:685 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a933f6 (byte 0x006a4cfd8), length 0x4000
09:43:756 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a98d31 (byte 0x006a634c4), length 0x4000
09:43:756 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a99d31 (byte 0x006a674c4), length 0x4000
09:43:885 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000001
09:43:885 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000001
09:43:886 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000057
09:43:886 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000057
09:43:887 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000057
09:43:887 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000001
09:43:887 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000057
09:43:887 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000001
09:43:887 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000057
09:43:888 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000001
09:43:888 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000057
09:43:888 Core\HW\WiimoteReal\IOWin.cpp:292 W[Wiimote]: IOWrite[WWM_WRITE_FILE]: Error on WriteFile: 00000057
09:43:907 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:43:985 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a901e1 (byte 0x006a40784), length 0x4000
09:43:985 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a911e1 (byte 0x006a44784), length 0x4000
09:44:076 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:44:109 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa23b9 (byte 0x006a88ee4), length 0x4000
09:44:109 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01aa33b9 (byte 0x006a8cee4), length 0x4000
09:44:167 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a915d2 (byte 0x006a45748), length 0x4000
09:44:170 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a925d2 (byte 0x006a49748), length 0x4000
09:44:238 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:44:482 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a90c4a (byte 0x006a43128), length 0x4000
09:44:484 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a91c4a (byte 0x006a47128), length 0x4000
09:44:631 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ab7963 (byte 0x006ade58c), length 0x4000
09:44:632 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ab8963 (byte 0x006ae258c), length 0x4000
09:44:814 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:44:853 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a6c0ed (byte 0x0069b03b4), length 0x4000
09:44:853 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a6d0ed (byte 0x0069b43b4), length 0x4000
09:44:959 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:45:315 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ad55a1 (byte 0x006b55684), length 0x4000
09:45:315 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ad65a1 (byte 0x006b59684), length 0x4000
09:45:408 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ab7eaa (byte 0x006adfaa8), length 0x4000
09:45:409 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ab8eaa (byte 0x006ae3aa8), length 0x4000
09:45:414 Core\HW\EXI\EXI_DeviceIPL.cpp:306 N[OSREPORT]: Freeing sound memory
09:45:421 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a995fc (byte 0x006a657f0), length 0x4000
09:45:421 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01a9a5fc (byte 0x006a697f0), length 0x4000
09:45:653 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ad5b84 (byte 0x006b56e10), length 0x4000
09:45:653 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01ad6b84 (byte 0x006b5ae10), length 0x4000
09:45:735 Core\IOS\DI\DI.cpp:170 I[IOS_DI]: DVDLowRead: offset 0x01df0609 (byte 0x0077c1824), length 0x4000
Seems to be tied to the Freeing of Sound Memory being much slower than console? You can improve the delays by HEAVILY overclocking the emulated CPU, but even that doesn't remove them. Something is broken.