Emulator

Enable virtual xfb.

With virtual xfb enabled i see same problem. With true xfb too.

Weird, could you post a video with it happening?

There is video and screenshots of video settings in dolphin.

I used a dolphin es_launch build and a non patched iso to test, with exact same settings as you, no issues here. Do you have sli perhaps? Try disabling it and use the dolphin build below with an unpatched iso(patched might work fine too, just in case).
after house of the dead 2 launches press alt +F5 to reconnect the wiimote and play.

http://www.emucr.com/2012/05/dolphin-eslaunch-git-30-641.html

I don't have sli. I try build which is your link. Trouble is still there. Unpatched iso just don't run house of the dead 2. But run House of the dead 3 and its work fine. Because of this i can't test this build with unpatched iso...

Es_build will run house of the dead 2 with the unpatched iso, just try it and reconnect your wiimote after house of the dead 2 launches. I honestly don't know what the problem might be in your case, it just doesn't exist here so it is definitely not a general issue.

OK tried to track down possible differences, i have the wiimenu installed and using the american version of the game.

Hmm i have black screen when i load unpatched HOTD2... i use europe version of the game.

You also need the wii nand installed to make it work, sorry about that. I also tried it without it installed and got a black screen too.

Okay. I google it and install wii nand. Unpatched iso start up? but problem still there. Maybe problem with my PC. Because no one don't have same problem.

http://www.youtube.com/watch?v=EeDv94IHpKk&feature=youtu.be
Here is a video of it working properly here along with the settings. Perhaps it is specific with the european version?

Maybe...i try settings which you use. Same problem. I try USA version...

Usa version don't flash but dolphin says Warning IOCTL_ES_LAUNCH: Game tried reload ios or a title that is not available in your nand dump
TitleID 0000000000000015.
Dolphin will likely hang now